Complexity in biomedicine

In this talk, I will discuss our recent advances in understanding phenotypic plasticity of cancer cells using a combination of experiments, analysis of big data and computational models of complex regulatory networks. Next, I will discuss our results on protein aggregation in neurodegenerative pathologies, such as Alzheimer's and Huntington's disease.

In particular, I will report on the importance of protein clearance from the endoplasmic reticulum to drive protein aggregation and on our recent results on huntingtin heterogenous aggregation in which mutated forms of the protein are able to form oligomers with non-mutated forms.

Contacts: paolo.finotelli@polimi.it
paolo.dulio@polimi.it